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All observations from preclinical (swine) models

( However, we previously observed in whole-animal experiments that not only the 2 AR-selective antagonist ICI-118551 but also the 1 AR-selective antagonist CGP20712A reduced tyramine-stimulated norepinephrine release in both spontaneously hypertensive (SHR) and normotensive (WKY) rats ( 1 AR, facilitating release of norepinephrine and epinephrine