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Canthaxanthin retinopathy with visual loss: a case report and review

Scenario 2: Fresh Blood with Uncertain Source Patient reports fresh blood in stool

This is not merely a speculative problem, because both a severely atypical melanocytoma and a melanocytoma-like classical melanoma will likely spread to the regional nodes, but only the latter will be candidates to sentinel node biopsy and, possibly, to an adjuvant therapy with BRAF -inhibitors or with immune checkpoint inhibitors (79, 80)

This is why the reported effects are not just pigmentation