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Circulation 137 , 11431157 (2018)

For this reason, smaller organoid systems may be preferred at the expense of low cellular diversity, loss of long-range connectivity, and electrophysiological properties that do not fully recapitulate disease states [225, 226]

Aggregate 2022, 3 (6), e285 10.1002/agt2.285

Some research suggests that our internal glutathione levels fluctuate according to our circadian rhythmour bodys 24-hour internal clock

Experimental evidence from diverse cell models indicates that CA IX acts here primarily via its catalytic activity and pH regulating function, which helps to maintain slightly alkaline intracellular pH that is critical for survival, metabolic performance, and proliferation of cancer cells, particularly in hypoxic conditions