foxo4 dri senescence The disordered p53 transactivation domain is the target of and the senolytic compound FOXO4-DRI FOXO4-DRI regulates endothelial cell senescence
FOXO4 DRI regulates endothelial cell senescence via the P53 signaling pathway PMC Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging PMC Peptide inhibitors targeting FOXO4 p53 interactions and inducing senescent cancer cell specific apoptosis bioRxiv FOXO4 DRI Results: What to Expect (2026) FOXO4 DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53 serine 15 phosphorylation Communications Biology
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