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While AEs associated with these agents have been investigated 19,36,37 , our analysis reveals critical gaps in understanding their NAEs given the central nervous system penetration and expanding indications of GLP-1 RAs

It is recruited to shelterin through a domain:peptide interaction between its TRF homology (TRFH) domain, also responsible for dimerisation of TRF1 (TRF1 TRFH ), and a short linear motif of TIN2, known as its TRFH-binding motif or TBM (TIN2 TBM

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All risks and benefits for the use of thiopurines in the context of COVID-19 should be considered (e.g