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22 HallmayerJ.ClevelandS.TorresA.PhillipsJ.CohenB.TorigoeT.et al

Mice received 9.2 0.9 MBq [ 18 F]FDG intravenously and were anesthetized with 2% isoflurane during a 50-min uptake period before the 15-min image acquisition

20 Primarily, NADPH provides reducing equivalents for fatty acid synthase (FASN), the main rate-limiting enzyme, to synthesize fatty acids with acetyl-CoA serving as a primer and malonyl-CoA as a two-carbon donor, 21,22 and provides the needed electrons for ironsulfur (Fe/S) protein assembly that participate in non-essential amino acid biosynthesis and lipoic acid synthesis, tRNA modification, DNA replication and repair, and telomere maintenance

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