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Front Immunol (2018) 9:850

Hemolytic jaundice is due to excess unconjugated or free bilirubin (also called indirect), so, even when it is very intense, it is never accompanied by choluria (acholuric jaundice) and pruritus, except when it coexists with a hepatobiliary disease (lithiasis and bile duct obstruction)

If untreated, NASH progresses to liver cirrhosis, scaring of the liver, and hepatocellular carcinoma

In other tissues, BPA is reported to increase expression of the estrogen-responsive genes cyp19a1b ( Aromatase B , neural aromatase), esr1 ( ER ), and esr2 ( ER ) and decrease expression of thyroid receptors TRa ( thraa, thrab ) and TRb ( thrb )