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Conditions such as atrophic gastritis (thinning of the stomach lining), Pernicious anemia (which makes it harder for your body to absorb Vitamin B12), Intestinal diseases such as crohns disease, celiac disease, bacterial growth and immune system disorders such as Graves disease or lupus can lead to Vitamin B12 deficiency in the body

This depends on your nutritional needs but, generally, B vitamin supplements are formulated to provide much more than you need and this can be a problem for the three B vitamins that can cause toxicity niacin, folate and B-6

However, it is best not to rely on over-the-counter medication for long periods